Natrii nucleinas (capsules 0.1 g)
International nonproprietary name
1 capsule contains 100 mg of sodium nucleinate.
1 vial (single-dose pack) contains 500 mg of sodium nucleinate..
Action of sodium nucleinate appears in induction of leukocytic reaction, stimulation of bone marrow performance, intracellular and nucleic metabolism, stimulation of T- and B-system and phagocytic immunity system, especially at immunodeficiency and antitoxic resistance of organism and diminution of toxic immunosupression properties of cytostatic agents (cyclophosphan), antibiotics, hormones and cardiac glycosides; tissue regeneration at dystrophies and ulcerative defects, including trophic ulcer of limbs, ulcerative diseases of stomach and duodenum, ulcerative colitis and other processes at which defects of immune system are registered; prevention or reduction of intensity of allergic reactions.
Pharmacokinetics ofsodium nucleinate is not described.
Sodium nucleinate is used in complex therapy as an immunomodulatory drug: at diseases accompanied by development of immunodeficiency (disease of upper air passages and various pneumonii, tuberculosis, rheumatism, ulcerative diseases of gastroduodenal region, herpetic keratitis, kidney and liver diseases, psychic disorders, etc.); at dystrophies and ulcerative processes, including tapetochoroidal dystrophy of retina; at parodontosis; at increased exercise stress (sportsmen) and work under extremal conditions; for increase of activity of low intensity immunogene vaccine and vaccination of people with immunodeficiency; for prophylaxis of postsurgical bacteritic complications and amelioration of wound healing; for treatment and prophylaxis of bacterial and professional intoxications; for regeneration of immune state at persons of elderly and senile age.
Direction for Use and Dosage Schedule
Sodium nucleinate is used for intake after meal. Single dose is 1-2 g in 2-4 intakes during the period from 2 weeks to 3 months and more.
Children are prescribed in the following doses: at the age under one year – 0.005 -0.01 g per intake, from 2 to 5 years – 0.015 – 0.05 g per intake, from 5 to 7 years – 0.1 g, from 8 to 14 years – 0.2 – 0.3 g 3-4 times a day.
Persons of elderly and senile age take the drug two times a year, in spring and in autumn by 1-1.5 g a day during 2-3 weeks with polyvitamins.
In case of leucopenia adults are prescribed by 0.1-0.2 g four times a day during the period of 10 days and more (depending on the clinical course). Sportmen are prescribed by 1-1.5 g per day in 2-3 intakes during the contest. As preventive measures for occupational hazard the drug is intaken in daily doses 1-1.5 g in courses of 2-3 weeks, 1-2 times a year. Sodium nucleinate therapy is conducted under the control of immune state.
Not described until now .
No contraindictions to using the preparation is revealed.
Small nuclear ribonucleic acid (RNA) and its sodium salt (sodium nucleinate) are natural preparations with physiological mechanism of action entering all the foodstuffs of herbal and animal origin, nontoxic, with no restrictions and incompatibility with other drugs.
Interaction with other drugs
At using the drug in cases of acute bacterial infections sodium nucleinate is used together with antibiotics.
Undesirable drug interaction at prescription of sodium nucleinate together with other drugs is not described.
No effects of overdose while using the drug are detected.
Form of Production
Capsules containing 100 mg. 10 capsules being in contour cellular packs. 3 contour cellular packs in a parcel.