Gentamycin sulphate (0,3% solution (eye drops))

Solutio Gentamicini sulfatis 0,3% (guttae ophthalmicae)

International nonproprietary name (INN)

Gentamycin

Gentamycin.

Pharmacotherapeutic group

Antibiotic of aminoglycosides

Composition

1 ml sterile solution (eye drops) contains 3 mg of gentamycin sulphate.

Pharmacological effect

Pharmacodynamics

Gentamycin is characterized of vast gamma of antibacterial actions. It is active to the majority of gram-negative: Escherichia coli, Klebsiella spp., indole-positive and indole-negative Proteus spp., Enterobacter spp., Providencia stuartii, Salmonella spp., Shigella spp., Acinetobacter spp.; anaerobic gram-positive coccus: Staphylococcus spp. (resistant to penicillin inclusive). Bacterium resistance t o gentamycin develops slowly still the strains resistant to neomycin and canamycin, are resistant also to gentamycin.

Pharmacokinetics

Practically not absorbed in blood under instillation in conjunctival sac. Absorbed in the humid front chamber of eye, vitreous body and cornea tissue, no absorption to lens. Max.level of gentamycin is detected in 30 minutes, then the concentration falls mainly due to elution by lacrimal liquid and is maintained at the therapeutic level during 6 h.

Indication for usage

Eye drops are administered in acute and chronic conjunctivitis, cornea ulcer, keratitis, keratoconjunctivitis, acute and chronic iritis, acute and chronic blepharitis, dacriocystitis and other infection-inflammatory eye diseases as well as to prevent and treat purulent complication in post operative period.

Administration and dosage

Instill 1-2 drops in conjunctival sac 3-4 times a day. The period of treatment up to 14 days.

Adverse reaction

Possible burning and irritation in eyes, hyperemia of conjunctive. Rare possible allergic reaction.

Contraindications

Hypersensitivity to preparation, grave renal dysfunction. Prohibited in patients with auditory nerve disease, vestibular apparatus and pregnancy.

Safety measures

Administer with care to patients with hypersensitivity to aminoglycosides. In long treatment control renal function and organs of hearing.

Interaction with other drugs

Forbidden concurrent administration with antibiotics of oto- or nephrotoxic action. Possible co-administration with corticosteroids.

Antibiotic activity is inhibited by cations of sodium, calcium, magnesium, and anion series (sulphate, phosphate, nitrate).

Overdose

Multiinstillation (more than 5) daily within a week causes edematic chemosis of stroma of cornea.

Dosage form

Gentamycin sulphate solution 0,3% (eye drops) in tube-dropper 1 ml.