Taufon (solution 4% (eye drop))

Taufonum (guttae ophthalmicae)

International nonproprietary name

Taurine.

Synonims

Tauforine solution 4%.

Composition

1 ml ofpreparation contains 40 mg of taurine.

Pharmacology group

Preparation for eye pathology treatment. Preparation regulating metabolic processes.

Pharmacology action

Pharmacodynamics

Taufonisasulfur-containingamineacidthatformsintheorganismduringcysteinetransformationprocess. The preparation enhances energetic processes, stimulates reparation and regeneration processes on diseases of dystrophic nature and on diseases accompanied by an acute impairment of tissue metabolism. Being a sulfur-containing amine acid, the preparation contributes to the normalization of cell membrane function, improves energetic and metabolism processes, maintains the persistence of electrolytic composition of cell cytoplasm, inhibits the synaptic transmission (performs a neurotransmitter function).

It induces the normalization of eye tissue metabolism on diseases of dystrophic nature.

Pharmacokinetics

After instillation it is absorbed in microquantities. It is practically not subject to oxidation in the organism tissues. It is found in the free form in the liver, in the muscles, in heart, nerve and brain tissues, in the blood (in blood corpuscles more than in the plasma). Itisexcretedbythekidney.

Indication

The preparation is prescribed to adults on dystrophic retina diseases (comprising inherited retinal abiotrophy), cornea dystrophy, senile cataract, trauma cataract, irradiation cataract and other types of cataracts, as well as on  cornea trauma (as a stimulator of reparation processes).

Routeofadministrationanddosage

For cataracts taufon is prescribed in the form of instillation 1 – 2 drops 2—4 times a day during 3 months. The course is repeated with a month interval. On traumas the preparation is used in the same dose during one month.

For treatment of dystrophic diseases of retina and cornea penetrating wound, taufon is administered under the conjunctiva in the dose of 0,3 ml of 4% solution once a day during 10 days. The course shall be repeated in 6 – 8 months.

On glaucoma (open-angle) the preparation is used as eye drops (instillation) 2 times a day 20—30 before instillation of timolol.

Side effects

Allergic reactions.

Contraindications

Higher sensitivity to taurine.

Interactionwithothermedications

In patients with glaucoma (open-angle) it has been demonstrated a significant increase of hypotension action in case of combination with timolol. The enhancement of effect is achieved by increasing the outflow easiness rate and reducing the aqueous hydatoid production.

Overdosing

Casesofoverdosingonusingthetaufoneyedropshavenotbeenspecified.

Product form

Solution 4% (eye drops) in vials 5 ml.