LIDASA (dried powder for preparation of injection solution, U64)
International nonproprietary name (INN)
The drug contains hyaluronidase enzyme (64 units in 1 vial).
The active substance is hyaluronidase. Specific substrate of hyaluronidase is hyaluronic acid: the enzyme breaks the chain between С1 acetamidodeoxyglucose and С4 glucuronic acid. The drug reduces the viscosity of hyaluronic acid. It increases tissue permeability, improves their trophism, increases the elasticity of scary places, enhances the resorption of haematoma, eliminates contractions, increase articulation motion. It facilitates fluid diffusion in intratissue space (spreading factor). Hyaluronidase action is reversible: less its concentration, the viscosity of hyaluronic acid is recovered. S.c.injection: effectdurationis 48 h.
Main indication for lidasa administration: articulation contracture, post-burn and post-intervention scars, ankylosing spondylitis, haematoma, scleroderma, traumatic injury of plexus and peripheral nerves (plexitits, neuritis), severe diseases of lumbar disks.
In ophthalmic practice lidasa is administered for thinner scarring of injured cornea areas. It is introduced in temple skin in case of retinopathy, in conjunctiva, retrabulbary, in vitreous body in case of hemorrhage.
Lidasa is administered as injections and inhalations in complex therapy to increase the concentration of antibacterial agents in lesion focus in patients with pulmonary tuberculosis of productive nature of inflammation.
Lidasa is also administered to aссelerate the absorption of medicines injected s.c. and i.m. (local anesthetics, miscle relaxants, isotonic solutions and others).
Lidasa is specially purified drug for parental (s.c. and i.m.) and inhalation intake. For injections dissolve the content of the vial in 1 ml of isotonic solution of sodium chloride or in 1ml of 0.5% of novocaine; for inhalation in 5 ml of isotonic solution of sodium chloride.
In therapy of articulation/scar contraction, ankylosing spondylitis, tendovaginitis, haematoma and others, introduce the ledasa solution (U64 in 1 ml) s.c. close to injury or in scar-abnormal tissue. Inject daily or in a day, the course is 6—10—15 and more injections. Therapeutic effect is manifested by scar softening, articulation mobility, elimination or reduction of contractions, haematoma resorbtion; the effect is mostly evident at the initial stages of the pathologic process.
In patients traumatic injury of plexus and peripheral nerves (brachial plexitis after bruise, traumatic mononeuritis and others), inject the drug s.c. in the injured nerve area (U64 in novocaine solution) in a day, the course is 12—15 injections. If necessary, repeat the course.
In patients with pulmonary tuberculosis of productive nature of inflammation administer lidasa inhalation daily, once day, 5 ml of the If necessary, repeat the course with an interval of 1.5—2 months. In addition, in this group of patients administer lidasa injections: 1 ml of the solution (U64) s.c. or i.m. daily or in a day. The course is10—20 injections.
The drug is usually well tolerated. In single cases possible allergic reaction, pain or infiltration in the area of the injection. Rare ventricular fibrillation under drug treatment.
Lidasa is contraindicated in individual hypersensitivity to the drug, malignant neoplasm, acute inflammation and infection, pulmonary hemorrhage an в hemoptysis, pulmonary tuberculosis with respiratory failure, the latest vitreous body hemerrhage.
Perform test to hyaluronidase sensitivity before usage of the drug (s.c. 0.02 ml of the drug). Avoid lidasa injection in the area of infection, acute inflammation, tumor, administer with care in combination with other drugs (possible unpredictable enhancement of absorption and systematic effect). Avoidconcurrentadministrationwithestrogen. Inpregnancyandlactationadministerundervitalnecessityonly.
Interaction with other drugs
Lidasa enhances drug absorption injected s.c, or i.m., and anesthesia of local anesthetics.
Symptoms: fever, nausea, vomit, vertigo, tachycardia, anesthetic and hypotenisa, local edema, erythema.
Treatment: injection of adrenalin, glycocorticoids, administration of antihistaminic.
Driedpowder (frozen-dried) forpreparationoftheinjectionsolutionU64 inglassvials.