Mucosat (10% solution of chondroitin sulfate for injections)
International nonproprietary name
Chondroitin sulfate.
Formulation
1 ml of solution for injections contains 100 mg of chondroitin sulfate.
Pharmatherapeutic Group
Metabolism compensator of bone and cartilage tissue.
Pharmacological Action
Pharmacodynamics
Main active agents of preparation are sodium salts of chondroitin sulfate A and C (average molecular weight is 11000 daltons). Chondroitin sulfate is high-molecular mucopolysaccharide. It is the basic component of proteoglycans, making together with collagenous fibers cartilaginous matrix.
The preparation inhibits the process of degeneration and stimulates regeneration of cartilage tissue, have hondroprotective, antiinflammatory, analgesic effect. It replaces chondroitin sulfate of articular cartilage, catabolised with pathologic process. It suppresses activity of enzymes bringing on degradation of articular cartilage: inhibits metalloproteinases, especially leukocytic elastase. It lowers activity of hyaluronidase, partially blocks emission of free oxygen radicals; promotes blocking of chemotaxis, antigenic determinants. It stimulates generation of proteoglycans by chondrocites. It influences phosphoric- potassium metabolism in cartilage tissue. It permits to restore mechanical and elastic consistency of cartilaginous matrix. Anti-inflammatory and analgesic effects are achieved due to resolution of release into synovial fluid of inflammation mediators and pain factors through syniviacites and macrophages of synovial membrane as well as owing to inhibiting secretion of leukotriene B4 and prostaglandin E2.
Application of the preparation enables to restoration of articular bursa and articular cartilage surface, prevents from constriction of connective tissue, performs the role of lubrication for articular surfaces, normalizes production of glenoid fluid, improves mobility of joints, promotes to reduction of pain intensity, improves quality of life.
Chondroitin sulfate retards resorption of bone tissue and relieves the loss of calcium, accelerates mobilization processes of bone tissue.
Pharmacokinetics
After intramuscular introduction chondroitin sulfate penetrates into synovial fluid. Maximum concentration in synovial fluid is achieved in 4-5 hours after injection. It is excreted from organism within 24 hours. It is predominantly eliminated by kidneys.
Therapeutic Indications
Degenerative diseases of joints and spinal column: primary arthrosis, intervertebral osteochondrosis.
Direction for Use and Dosage Schedule
The preparation is introduced intramuscularly in a dose of 1 ml every other day. Provided good tolerance dose is increased to 2 ml starting from the fourth injection. Course of treatment is 25-35 injections. Refresher course of treatment is prescribed in 6 months.
Prescription of preparation to children is solved by a doctor individually depending on clinical situation.
Particular Indications
To achieve stable clinical effect there is required minimum 25 injections of chondroitin sulfate, but the effect is preserved for a long time within many months after termination of the course of treatment.
Adverse Reaction
At preparation intake allergic reactions, hemorrhages are possible in the site of injection.
Contraindications
Increased individual sensitivity to any of the components of the preparation, susceptibility to bleeding sickness, thrombophlebitis, pregnancy, lactation (treatment cessation during breast-feeding ).
Precautions
Treatment cessation at allergic reactions or hemorrhages.
Interaction with other drugs
In combination with nonsteroidal anti-inflammatory drugs chondroitin sulfate allows to lower dosage of nonsteroidal anti-inflammatory drugs.
Form of Production
10% solution for injections in ampuls containing 1 and 2 ml. 5 ampuls inserted into contour cellular pack.
