Acyclovir (5 % ointment)

Unguentum Acуcloviri 5 %

 

International nonproprietary name

Acyclovir.

Acyclovir.

Pharmacotherapeutic group

Antiviral (antiherpetic) agent.

Composition of the preparation

100 gointment contains 5 gacyclovir.

Pharmacological action

Pharmacodynamics

Acyclovir shows activity in relation to herpes simplex virus (Herpes simplex) 1 and 2 types, shingles virus (Varicella zoster), and also Epstein-Barra virus. Cytomegalovirus is less sensitive to acyclovir action. The molecular and biological mechanism of acyclovir antiviral activity is due to competitive interaction with virus thymidine kinase and step-by-step phosphorylation with formation of mono-, di- and triphosphate. Acyclovir triphosphate is built in instead of deoxyguanosine in virus DNA, inhibits DNA-polymerase of the last and suppresses replication process. At herpes acyclovir  prevents the formation of new elements of an eruption, reduces probability of dermal dissemination and visceral complications, accelerates formation of crusts. Promotes pain relief in an acute phase of shingles.

Pharmakokinetics

At local use practically does not enter in systemic blood flow.

Indications 

Acyclovir 5 % ointment is indicated at infections of skin and mucosa caused by virus of simple herpes, including primary and relapsing genital herpes; for prophylaxis of the infections caused by virus of simple herpes in patients with immune system disorders; at primary and relapsing infections caused by shingles virus in patients without immunity disorders.

Dosage and method of administration

Acyclovir 5 % ointment should be applied externally. The preparation is indicated five times a day in a center of lesion with an interval of 4 hours. The course of treatment is 5-10 days.

Special indications

Treatment is recommended to start at the very first signs of disease. Application of the ointment is recommended to be carried out in rubber gloves with the purpose of other sites of skin prevention from infection.

Side effects

Local irritation of mucosa disappearing after the preparation withdrawing is possible in single cases. There can be scaling of small skin regions at long-term application of ointment for separate patients.

Contraindications

The high individual sensitivity to the preparation.

The form of release

5 % ointment in 2 g, 5 gand 10 g tubas.